Nole reached his ninth US Open quarter-final with a 6-3, 4-6, 6-4, 6-3 victory over Roberto Bautista Agut after three hours and three minutes of play.
2011 champion reached the fourth round at Flushing Meadows on Friday, edging Andreas Seppi 6-3, 7-5, 6-4 in two hours and 28 minutes.
2011 champion moved into the third round of the US Open as he defeated Andreas Haider-Maurer of Austria 6-4, 6-1, 6-2.
The top seed needed just 70 minutes to routinely beat Joao Souza 6-1, 6-1, 6-1 in their first-round match at the US Open 2015 on Monday.
The 2011 US Open champion participated in the 20th Annual Arthur Ashe Kids’ Day, packed with entertainment and fun for all ages.
Top seed and 2011 champion will open campaign in his 11th US Open appearance against Joao Souza (Brazil, ATP #89) on Monday.
Djokovic has joined Audrey Hepburn, David Beckham, Harry Belafonte, Sir Roger Moore, Shakira, Maxim Vengerov, Serena Williams, and others.
This is Novak’s fifth runner-up finish in Cincinnati, following his Final appearances in 2008-09 and 2011-12.
Novak stays on course in historic bid to become the first player to complete the Career Golden Masters with a 4-6, 7-6, 6-2 win over Dolgopolov.
Nole reached the last four at the Cincinnati Masters on Friday as he outplayed no.5 seed Stan Wawrinka 6-4, 6-1 in a rematch of the French Open final.