Novak is a two-time defending champion and no.1 seed. He will open quest for 20th Masters crown in R2 against Dominik Thiem.
Nole won his 46th tour-level title when he defeated Tomas Berdych 6-0, 6-2 in the China Open final, improving to a perfect 24-0 at the ATP 500 event.
Novak beat no.6 seed Andy Murray 6-3, 6-4 in one hour and 36 minutes to reach his fifth final at the China Open.
Nole is through to the last four in Beijing with a 6-2, 6-4 victory over no.5 seed Grigor Dimitrov.
Defending champion reached the China Open quarter-final after a 6-3, 7-5 defeat of Vasek Pospisil on Wednesday at the Beijing Olympic Green Tennis Center.
After his first round win at the China Open on Tuesday, Nole took time to answer about 20 most interesting questions from his fans.
Nole moved to 20-0 at the China Open with a 6-2 6-1 win over Spaniard Guillermo Garcia-Lopez on Tuesday.
The ATP 500 event begins on Monday, September 29, and features five players from the top 10.
World no.1 and the China Open organisers partnered up on Friday to host a charity event for the children of China and Serbia.
2010 champions, Serbia, have been handed a home tie against Croatia in the World Group first round next season.