Tomas Berdych is into the last four at The Championships after Novak retired with an elbow injury early in the second set.
Three-time former champion beat Adrian Mannarino 6-2, 7-6 (5), 6-4 to move into his ninth Wimbledon quarter-final.
Three-time former champion booked his place in the Wimbledon last 16 with a comprehensive 6-4, 6-1, 7-6 victory over Ernests Gulbis.
The second seed clinched a one-way win on No.1 Court over Adam Pavlasek 6-2, 6-2, 6-1. He next faces Ernests Gulbis of Latvia.
Novak is through to the second round of Wimbledon after Martin Klizan pulled out with a calf injury, trailing 3-6, 0-2, 0/30.
The victory over Gael Monfils in the Aegon International final gives Nole his fourth grass-court crown and first outside Wimbledon.
Nole will take on Gael Monfils (2) on Saturday, seeking his first title on grass outside Wimbledon.
Gentlemen’s singles draw has been made for Wimbledon, the most prestigious tennis tournament in the world (July 3-16).
The top seed advanced into the Aegon International last four with a 6-2, 7-6 (9) win over American Donald Young.
Novak got his grass campaign underway with a 6-4, 6-3 victory over qualifier Vasek Pospisil in 85 minutes.
07.08. - 13.08.2017.