Nole is through to the last four in Beijing with a 6-2, 6-4 victory over no.5 seed Grigor Dimitrov.
Defending champion reached the China Open quarter-final after a 6-3, 7-5 defeat of Vasek Pospisil on Wednesday at the Beijing Olympic Green Tennis Center.
Nole moved to 20-0 at the China Open with a 6-2 6-1 win over Spaniard Guillermo Garcia-Lopez on Tuesday.
The ATP 500 event begins on Monday, September 29, and features five players from the top 10.
2010 champions, Serbia, have been handed a home tie against Croatia in the World Group first round next season.
Novak will defend four ATP titles from September 29 to November 16: Beijing, Shanghai, Paris and the ATP World Tour Finals in London.
No.10 seed Kei Nishikori upset the top seed in four sets – 6-4, 1-6, 7-6 (4), 6-3, becoming the first Asian man to reach a Grand Slam singles final.
Novak reached his eighth consecutive US Open semi-finals with a 7-6 (1), 6-7 (1), 6-2, 6-4 win over Andy Murray on Wednesday night.
2011 titlist powered into the last eight at Flushing Meadows on Monday, with a 6-1, 7-5, 6-4 victory over no.22 seed Philipp Kohlschreiber.
2011 champion advanced to the fourth round in New York on Saturday as he dismissed Sam Querrey 6-3, 6-2, 6-2.