Nole extended his unbeaten run to 28 matches with a comfortable 6-3, 6-0, 6-2 victory over Fabio Fognini on Sunday. He next faces Stanislas Wawrinka.
World no.2 and defending champion reached the fourth round of the Australian Open beating Denis Istomin 6-3, 6-3, 7-5.
With temperatures surpassing 40 Celsius, Nole appeared content to expend as little energy as possible. He beat Leonardo Mayer 6-0, 6-4, 6-4.
Novak advanced to the second round of the 2014 Australian Open with a 6-3, 7-6 (2), 6-1 win over Lukas Lacko of Slovakia on Monday.
Novak is no.2 seed. He will start his bid for a seventh Grand Slam title against world no.90 Lukas Lacko of Slovakia.
Novak put together some fantastic tennis to beat Juan Monaco 7-5, 6-1 at the AAMI Kooyong Classic in Melbourne.
Nole made his first appearance on center court, Rod Laver Arena, before the start of Australian Open 2014.
Nole beat world no.3, Spaniard David Ferrer, 7-5, 6-2 in the World Tennis Championship final on Saturday to capture his third crown in Abu Dhabi.
World no.2 beat Frenchman Jo-Wilfried Tsonga 7-6 (5), 6-3 in the semi-finals at the Zayed Sports City in Abu Dhabi on Friday.
Nole will play Tsonga (def. Murray) in the semi-finals on December 27 (about 14.00 CET).