Novak has withdrawn from the Mubadala WTC exhibition event due to pain in his right elbow. The Serbian star was scheduled to return to tennis on Friday, December 29, after being out of the game for nearly six months.
Tomas Berdych is into the last four at The Championships after Novak retired with an elbow injury early in the second set.
Three-time former champion beat Adrian Mannarino 6-2, 7-6 (5), 6-4 to move into his ninth Wimbledon quarter-final.
Three-time former champion booked his place in the Wimbledon last 16 with a comprehensive 6-4, 6-1, 7-6 victory over Ernests Gulbis.
Nole will take on Gael Monfils (2) on Saturday, seeking his first title on grass outside Wimbledon.