Novak beat world no.35 Jack Sock 6-2, 6-1 in just 54 minutes to move into the Rogers Cup quarter-finals.
Nole and Janko upset no.4 seeds Rohan Bopanna (IND) and Florin Mergea (ROM) 6-3, 5-7, 10-3 to reach quarter-finals in Montreal.
Nole advanced into the Canada Masters last 16 with a 6-3, 7-6 (4) victory over Thomaz Bellucci (BRA) on Tuesday night.
Serbian duo of world no.1 Novak Djokovic and former world no.8 Janko Tipsarevic beat Viktor Troicki and Andreas Seppi 6-4, 6-3.
Novak is a top seed and has a first round BYE. He will open campaign against Thomaz Bellucci (BRA) on Tuesday.
Novak will be leading the Singapore Slammers in the second season of the 2015 Coca-Cola International Premier Tennis League (IPTL).
Novak starts his US Open Series campaign at the Rogers Cup, taking place in Montreal, Canada, from August 10-16.
In the latest ATP Ranking list, Djokovic has 13,845 points. He is followed by Roger Federer (9,665) and Andy Murray (7,810).
Novak successfully defended his Championships title, defeating seven-time former winner Roger Federer in four sets 7-6 (1), 6-7 (10), 6-4, 6-3.
Nole will play in his fourth Wimbledon final on Sunday after he beat no.21 seed Richard Gasquet 7-6, 6-4, 6-4 in two hours and 21 minutes.