Nole arrived in Indian Wells for the first of nine ATP World Tour Masters 1000 events, the BNP Paribas Open (March 6-16).
Novak came back from a break down in both sets to beat defending champion David Ferrer 7-5, 7-5 and win his 40th career trophy.
Novak will play against defending champion, Spaniard David Ferrer (3), for his second BNP Paribas trophy (Sunday at 15.00 CET).
Novak is through to the BNP Paribas Masters last four with a 6-1, 6-4 win over Stanislas Wawrinka. He goes on to face no.5 seed Roger Federer.
Novak came back from a set down to beat no.13 seed, American John Isner, 6-7 (5), 6-1, 6-2 in one hour and 50 minutes.
Nole defeated world no.189, French qualifier Pierre-Hugues Herbert, 7-6 (3), 6-3 in one hour and 33 minutes to reach the last 16.
Novak is no.2 seed and will open his campaign in round two against world no.189, qualifier Pierre-Hugues Herbert (Tuesday about 21.00 CET).
Novak won his 39th career crown and 15h Masters trophy when he beat Juan Martin del Potro 6-1, 3-6, 7-6 (3) in Shanghai Masters final.
Novak is through to his second successive Shanghai Rolex Masters final with a 6-2, 7-5 win over Frenchman Jo-Wilfried Tsonga (7).
Defending champion came back from a set down to beat Gael Monfils 6-7 (4), 6-2, 6-4 and progress to Masters 1000 event last four.