Novak won his fourth Internazionali BNL d’Italia crown with a 6-4, 6-3 victory over second seed Roger Federer on Sunday.
Novak will contest his sixth final at Foro Italico on Sunday (16:00 CET) when he meets no.2 seed Roger Federer.
Defending champion advanced to his sixth semi-final in Rome as he beat no.5 seed Kei Nishikori 6-3, 3-6, 6-1 on Friday.
Nole rallied from a set down to defeat Thomaz Bellucci 5-7, 6-2, 6-3 on Thursday and reach the quarter-finals at Foro Italico.
Top seed and defending champion beat Nicolas Almagro 6-1, 6-7 (5), 6-3 to reach the last 16 at the Internazionali BNL d’Italia on Tuesday.
Last year Nole lifted his third trophy in Rome recording victories over Radek Stepanek, Philipp Kohlschreiber, David Ferrer, Milos Raonic and Rafael Nadal.
With a 7-5, 4-6, 6-3 win over Tomas Berdych, Novak became the first player ever to win the opening three ATP World Tour Masters 1000 events of the season.
Top seed and 2013 titlist beat eight-time former champion Rafael Nadal 6-3, 6-3 in the Monte-Carlo Rolex Masters blockbuster semi-final.
Novak beat no.8 seed Marin Cilic 6-0, 6-3 in 65 minutes to reach the Monte-Carlo Rolex Masters last four on Friday.
Nole cruised into the Monte-Carlo Rolex Masters quarter-finals, knocking out world no.52 Andreas Haider-Maurer (AUT) 6-4, 6-0 in just 56 minutes.