Novak suffered a quarter-final 6-2, 5-7, 4-6 loss to sixth-seeded Tomas Berdych at the Foro Italico on Friday.
Novak beat world no.23 Alexandr Dolgopolov of Ukraine 6-1, 6-4 to reach the last 8 at the Internazionali BNL d’Italia on Thursday.
Nole eased to a 6-2, 6-3 victory against Spaniard Albert Montanes in 70 minutes on Tuesday to reach the last 16 at the Foro Italico.
Top seed and two-time former champion Novak Djokovic has a first-round BYE. He will open quest for his third title against world no.89, Spanish qualifier Albert Montanes.
World no.28 Grigor Dimitrov ended Novak’s Mutua Madrid Open campaign with a 7-6(6),
6-7(8), 6-3 win in three hours and four minutes on Tuesday.
After victory in Monte Carlo two weeks ago, Nole continues his clay court season at the second ATP World Tour Masters 1000 tournament on clay in 2013, the Mutua Madrid Open.
Novak will take part at the Mutua Madrid Open next week (May 5-12), where he will defend quarterfinal performance and 180 ATP points.
Novak captured his first Monte-Carlo Rolex Masters title with a 6-2, 7-6 (1) win over eight-time champion Spaniard Rafael Nadal.
The world no.1 eased past no.32-ranked Italian Fabio Fognini 6-2, 6-1 in just 51 minutes to reach his third Monte-Carlo Rolex Masters final.
Novak advanced to the Monte-Carlo Rolex Masters last four with a 6-4, 6-3 victory over Jarkko Nieminen in 77 minutes.