The top seed beat Andy Murray (GBR, 8) in straight sets, 7-5, 6-2, to progress into the BNP Paribas Masters semi-final on Friday.
Novak continued his quest for back-to-back titles at the BNP Paribas Masters with a 6-3, 7-6 (2) win over home favourite Gael Monfils on Thursday.
Defending champion recorded a 6-3, 6-4 win over Philipp Kohlschreiber (24) for a place in the last 16 of the Masters 1000 event.
The ninth and final ATP World Tour Masters 1000 event of the season is taking place in Paris from October 27 to November 2.
Novak suffered semi-final exit at the Shanghai Rolex Masters on Saturday, after falling to no.3 seed Roger Federer 4-6, 4-6.
Novak recorded a convincing 6-4, 6-2 win over no.5 seed David Ferrer on Friday to advance into the Masters 1000 event last four.
Nole beat Mikhail Kukushkin 6-3, 4-6, 6-4 to advance into the Shanghai Rolex Masters last eight.
Novak moved to last 16 at the Shanghai Rolex Masters with a 6-3, 6-4 victory over 21-year-old Austrian hope Dominik Thiem (ATP #39).
Novak is a two-time defending champion and no.1 seed. He will open quest for 20th Masters crown in R2 against Dominik Thiem.
No.16 seed Tommy Robredo stunned world no.1 and four-time former runner-up 7-6 (6), 7-5 in R3 of the Western & Southern Open on Thursday.