World no.1 arrived in Madrid with a 28-2 record on the season. The 2011 champion will open campaign against either Borna Coric (CRO) or Nicolas Almagro (ESP).
World no.55 Jiri Vesely ended Novak’s Monte-Carlo Rolex Masters campaign with a 6-4, 2-6, 6-4 win in two hours and six minutes on Wednesday.
Novak is a top seed and has a first-round BYE. He will open his campaign against world no.55 Jiri Vesely (CZE).
World no.1 continued his impressive run of form, winning the Miami Open over Kei Nishikori 6-3, 6-3 at Key Biscayne on Sunday.
Novak reached his 40th career ATP Masters 1000 final and will attempt to win record 28th Masters crown on Sunday.
Nole produced a commanding display on Wednesday night to beat Tomas Berdych 6-3, 6-3 and set up clash with David Goffin.
Novak defeated no.14 seed Dominic Thiem to reach the Miami Open presented by Itaú last eight. He next faces Tomas Berdych (CZE, 7).
Nole earned a place in the fourth round of the 2016 Miami Masters with a 6-4, 6-1 win over no.33 seed Joao Sousa on Sunday.
The defending champion advanced with a 6-3, 6-3 victory over Kyle Edmund (GBR) on Friday evening.
World no.1 and five-time champion is a top seed and has a first round BYE. He will open title defence against Kyle Edmund.