The ninth and final ATP World Tour Masters 1000 event of the season is taking place in Paris from October 27 to November 2.
Novak suffered semi-final exit at the Shanghai Rolex Masters on Saturday, after falling to no.3 seed Roger Federer 4-6, 4-6.
Novak recorded a convincing 6-4, 6-2 win over no.5 seed David Ferrer on Friday to advance into the Masters 1000 event last four.
Nole beat Mikhail Kukushkin 6-3, 4-6, 6-4 to advance into the Shanghai Rolex Masters last eight.
Novak moved to last 16 at the Shanghai Rolex Masters with a 6-3, 6-4 victory over 21-year-old Austrian hope Dominik Thiem (ATP #39).
Novak is a two-time defending champion and no.1 seed. He will open quest for 20th Masters crown in R2 against Dominik Thiem.
No.16 seed Tommy Robredo stunned world no.1 and four-time former runner-up 7-6 (6), 7-5 in R3 of the Western & Southern Open on Thursday.
The top seed battled past world no.31 Gilles Simon 6-3, 4-6, 6-4 on Tuesday evening in the second round of the Western & Southern Open.
Nole starts his Cincinnati Masters campaign in the second round against world no.31 Gilles Simon.
Frenchman Jo-Wilfried Tsonga ended Novak’s 2014 Rogers Cup campaign with a 6-2, 6-2 win in 63 minutes on Thursday.