Novak is a top seed and will open his title defence in the second round against Martin Klizan, on Saturday at 20:00 local time (Sunday at 01:00 CET).
Nole beat second seed Roger Federer 6-3, 6-7 (5), 6-2 to capture his fourth Indian Wells crown and 21st ATP Masters 1000 title.
Novak is aiming to become the 12th player in the Open Era to win 50 titles. He will face no.2 seed Roger Federer on Sunday.
Defending champion secured his spot in the last eight with a 6-4, 7-6 (5) win over no.18 seed John Isner.
The top seed recorded a 7-5, 6-3 win over Albert Ramos-Vinolas (68) to reach the BNP Paribas Open R4 on Monday evening.
Nole opened his title defence at the BNP Paribas Open with a 6-1, 6-3 win over Marcos Baghdatis, moving to a 37-6 record at the ATP World Tour Masters 1000 event.
Novak will begin title defence in Indian Wells against Marcos Baghdatis on Saturday at 19.00 local time (Sunday at 03.00 CET).
Novak won the BNP Paribas Masters for the third time on Sunday as he defeated Milos Raonic 6-2, 6-3 in the final.
Nole powered into the Paris Masters final with a 6-2, 6-3 victory over no.6 seed Kei Nishikori in just 62 minutes.
The top seed beat Andy Murray (GBR, 8) in straight sets, 7-5, 6-2, to progress into the BNP Paribas Masters semi-final on Friday.