Novak is heading to Indian Wells where the first ATP World Tour Masters 1000 event of the season, the BNP Paribas Open, begins on March 9.
Novak advanced past the Argentine 4-6, 6-4, 6-4 in two hours and 38 minutes to move to 12-4 in their ATP Head2Head series.
The top seed eliminated Martin Klizan 6-3, 7-6 (4) to reach the second round of the ATP World Tour 500 tournament in Mexico.
Nole is no.1 seed and will open his Abierto Mexicano Telcel campaign against world no.65 Martin Klizan.
The top seed retired at 3-6 in his quarter-final match against Feliciano Lopez at the 2016 Dubai Duty Free Tennis Championships on Thursday.
The world no.1 joined an elite rank of players to win 700 matches after he beat Malek Jaziri 6-1, 6-2 in second round on Wednesday.
Novak cruised into the second round of the Dubai Duty Free Tennis Championships with a 6-1, 6-2 win over world no.41 Tommy Robredo.
Novak is making his tenth appearance at the Dubai Duty Free Tennis Championships, aiming for his fifth crown.
Novak captured his eighth ATP World Tour title of the season and 56th of his career over no.3 seed Rafael Nadal 6-2, 6-2, in the final of the China Open on Sunday.
Djokovic improved to a 28-0 lifetime mark at the China Open as he dismissed no.4 seed David Ferrer 6-2, 6-3 in semi-finals on Saturday.