The top seed retired at 3-6 in his quarter-final match against Feliciano Lopez at the 2016 Dubai Duty Free Tennis Championships on Thursday.
The world no.1 joined an elite rank of players to win 700 matches after he beat Malek Jaziri 6-1, 6-2 in second round on Wednesday.
Novak cruised into the second round of the Dubai Duty Free Tennis Championships with a 6-1, 6-2 win over world no.41 Tommy Robredo.
Novak is making his tenth appearance at the Dubai Duty Free Tennis Championships, aiming for his fifth crown.
Novak captured his eighth ATP World Tour title of the season and 56th of his career over no.3 seed Rafael Nadal 6-2, 6-2, in the final of the China Open on Sunday.
Djokovic improved to a 28-0 lifetime mark at the China Open as he dismissed no.4 seed David Ferrer 6-2, 6-3 in semi-finals on Saturday.
The top seed from Serbia enjoyed a crushing 6-2, 6-2 victory over John Isner (USA, 6) to book his place in the China Open last on Friday.
Novak defeated Ze Zhang 6-2, 6-1 in 55 minutes to advance to the last eight of the China Open.
Nole moved to 25-0 at the China Open with a 6-1 6-1 win over Simone Bolelli on Tuesday.
The ATP 500 event begins on Monday and features five players from the top 10. Novak will open his title defence against Italian qualifier Simone Bolelli.