Novak defeated the big hitting Argentine 6-4, 7-6 (3), 6-1 to progress in two hours and 15 minutes under the Arthur Ashe Stadium roof. Next up for the top seed is Denis Kudla (USA, ATP #111).
Novak started his title defence in a strong fashion by beating Roberto Caraballes Baena in straight sets, 6-4, 6-1, 6-4. He next faces Juan Ignacio Londero (ARG, ATP #56).
Defending champion advanced into the last 16 at the Western & Southern Open on Tuesday, following a 7-5, 6-1 win over world no.45 Sam Querrey. The match lasted one hour and 18 minutes.
The defending champion cruised through his fourth round match with a 6-3, 6-2, 6-3 victory over Ugo Humbert in one hour and 42 minutes, reaching the last eight of a major for the 45th time. He goes on to face no.21 seed David Goffin (5-1 H2H) on Wednesday.
The defending champion began his quest for a fifth Wimbledon title with a 6-3, 7-5, 6-3 victory over Philipp Kohlschreiber. He goes on to face ATP no.111 Denis Kudla, in round two on Wednesday.
The third Grand Slam of the season will be held from July 1-14, at the All England Lawn Tennis Club. In his 15th appearance at Wimbledon, Novak will open title defence campaign against world no.57 Philipp Kohlschreiber (GER) in their 13th career meeting (10-2 H2H).