Novak started his title defence in a strong fashion by beating Roberto Caraballes Baena in straight sets, 6-4, 6-1, 6-4. He next faces Juan Ignacio Londero (ARG, ATP #56).
The defending champion began his quest for a fifth Wimbledon title with a 6-3, 7-5, 6-3 victory over Philipp Kohlschreiber. He goes on to face ATP no.111 Denis Kudla, in round two on Wednesday.
Nole cruises into the second round after a comfortable win over Hyeon Chung 6-3, 6-2, 6-4.
Nole moved to 25-0 at the China Open with a 6-1 6-1 win over Simone Bolelli on Tuesday.