The sixth seed needed two hours to progress to the US Open last 8, beating Joao Sousa 6-3, 6-4, 6-3 on Arthur Ashe Stadium. He will next face John Millman (AUS)
Novak completed efficient 6-4, 6-2, 6-2 victory over unseeded Karen Khachanov to set up a last eight meeting with 24th seed Kei Nishikori. The match lasted one hour and 45 minutes.
Nole reached his 12th French Open quarter-final with a 6-3, 6-4, 6-2 win over Spain's Fernando Verdasco on Chatrier. The victory was his 200th triumph on clay courts. Next up for Novak is world no.72 Marco Cecchinato on Tuesday
Three-time former champion beat Adrian Mannarino 6-2, 7-6 (5), 6-4 to move into his ninth Wimbledon quarter-final.
Novak continued his good run on Parisian clay as he defeated Albert Ramos-Vinolas 7-6 (5), 6-1, 6-3 to reach the last 8.
The Serbian ace is in the final eight at a Grand Slam for the 28th consecutive time, surpassing Jimmy Connors for second best streak ever.
Novak defeated no.14 seed Dominic Thiem to reach the Miami Open presented by Itaú last eight. He next faces Tomas Berdych (CZE, 7).