Nole features in four of top 5 Grand Slam matches of the year.
Tonight’s match-up was the 37th between the pair. Nadal won 6-2, 3-6, 6-4, 6-1 in three hours and 21 minutes.
The top two players in the world will go to No.1 on list of great rivalries in Open Era when they meet on Monday, beating Lendl/McEnroe and Connors/Lendl (36).
The top seed came back from a set down twice to beat Stanislas Wawrinka 2-6, 7-6 (4),
3-6, 6-3, 6-4 and reach his fourth straight final in New York.
Novak leads the Head2Head career record against the Swiss 12-2, having won the past 11 meetings.
The 2011 champion set up a semi-final match with Stanislas Wawrinka with a 6-3, 6-2, 3-6, 6-0 victory over Russian Mikhail Youzhny.
The US Open top seed booked his place in the quarter-finals with a 6-3, 6-0, 6-0 victory over Marcel Granollers on Tuesday.
Novak moved into the fourth round at Flushing Meadows with a convincing 6-0, 6-2, 6-2 victory over Joao Sousa of Portugal.
World no.1 recorded a routine 7-6 (2), 6-2, 6-2 win over German’s Benjamin Becker in the second round of the US Open on Friday.
The 2011 US Open champion defeated Ricardas Berankis 6-1,
6-2, 6-2 in just 82 minutes to reach the 2nd round in New York.