Novak's US Open title defence came to a halt on Sunday when the Serb retired from his fourth-round match against Stan Wawrinka. The Swiss led, 6-4, 7-5, 2-1, when the top seed stopped due to a left shoulder injury. They were facing off for the first time since the 2016 US Open final.
Novak defeated the big hitting Argentine 6-4, 7-6 (3), 6-1 to progress in two hours and 15 minutes under the Arthur Ashe Stadium roof. Next up for the top seed is Denis Kudla (USA, ATP #111).
Novak started his title defence in a strong fashion by beating Roberto Caraballes Baena in straight sets, 6-4, 6-1, 6-4. He next faces Juan Ignacio Londero (ARG, ATP #56).
The main singles draw for the last Grand Slam tournament in 2019 has been made on Thursday. No.1 seed and defending champion will open campaign in his 14th US Open appearance against Roberto Caraballes Baena from Spain (ATP #76).
Novak claimed his 16th Major and fifth Championships crown with a thrilling four hours, 57-minute victory on Centre Court, adding to his 2011, 2014, 2015 and 2018 triumphs at the All England Lawn Tennis Club. It is Nole's third trophy in 2019 and 75th career title.
The defending champion cruised through his fourth round match with a 6-3, 6-2, 6-3 victory over Ugo Humbert in one hour and 42 minutes, reaching the last eight of a major for the 45th time. He goes on to face no.21 seed David Goffin (5-1 H2H) on Wednesday.