Top seed and 2011 champion will open campaign in his 11th US Open appearance against Joao Souza (Brazil, ATP #89) on Monday.
Novak successfully defended his Championships title, defeating seven-time former winner Roger Federer in four sets 7-6 (1), 6-7 (10), 6-4, 6-3.
Gentlemen’s singles draw has been made for Wimbledon, the most prestigious tennis tournament in the world (June 29 – July 12).
No.8 seed Stan Wawrinka denied Novak career Grand Slam dream with a 4-6, 6-4, 6-3, 6-4 victory in Roland Garros final on Sunday.
Novak beat nine-time French Open winner Rafael Nadal 7-5, 6-3, 6-1 in the most eagerly anticipated Grand Slam quarter-final on Wednesday.
The top seed advanced into the Roland Garros last eight with a 6-1, 6-2, 6-3 triumph over Richard Gasquet (FRA, 20) in two hours.
Top seed defeated rising Australian teenager Thanasi Kokkinakis in straight sets to reach the fourth round of the French Open for a ninth time.
Novak beat 55th-ranked Gilles Muller of Luxemburg 6-1, 6-4, 6-4 for a place in the third round of the 2015 Roland Garros.
Novak began his quest for a first Roland Garros crown with a 6-2, 7-5, 6-2 victory over 87th-ranked Jarkko Nieminen on Tuesday.
The second Grand Slam of the season, the Roland Garros, is taking place in Paris, from May 24 to June 7, 2015.