The second Grand Slam of the season, the Roland Garros, is taking place in Paris, from May 22 to June 5, 2016.
After winning Doha, the Australian Open and the first two Masters events in 2016, Novak is full of confidence ahead of the European clay-court swing.
The top seed scored a 6-1, 6-2, 7-6 (3) win over Quentin Halys (FRA) in one hour and 40 minutes to reach the third round in Melbourne.
Nole cruises into the second round after a comfortable win over Hyeon Chung 6-3, 6-2, 6-4.
Top seed and five-time defending champion will open campaign in his 12th Australian Open appearance against world no.51, Hyeon Chung.
With a simply outstanding performance, Novak defeated Roger Federer 6-4, 5-7, 6-4, 6-4 to win his 10th Grand Slam trophy.
Nole was in imperious form in his US Open semi-final against defending champion Marin Cilic on Friday (6-0, 6-1, 6-2).
Nole continued his quest for a third major title of 2015, when he beat no.18 seed Feliciano Lopez 6-1, 3-6, 6-3, 7-6 (2) on Tuesday night.
Nole reached his ninth US Open quarter-final with a 6-3, 4-6, 6-4, 6-3 victory over Roberto Bautista Agut after three hours and three minutes of play.
2011 champion reached the fourth round at Flushing Meadows on Friday, edging Andreas Seppi 6-3, 7-5, 6-4 in two hours and 28 minutes.