World no.1 progressed to his fifth semi-finals in Melbourne with a 7-6 (5) 6-4 6-2 victory over Milos Raonic.
Nole beat Gilles Muller 6-4, 7-5, 7-5 to reach the Australian Open quarter-finals for the eighth time.
The top seed advanced into the Australian Open fourth round with a 7-6 (8), 6-3, 6-4 win over no.31 seed Fernando Verdasco on Saturday.
Novak ousted world no.88 Andrey Kuznetsov in straight sets 6-0, 6-1, 6-4 in one hour and 24 minutes on Thursday to ease into the third round in Melbourne.
World no.1 opened his Australian Open campaign with a 6-3, 6-2, 6-4 win over qualifier from Slovenia Aljaz Bedene (116) on Tuesday.
Novak is a top seed. He will start his bid for an eighth Grand Slam title against Aljaz Bedene (SLO, Q) on Tuesday.
Novak features in two of top 5 Grand Slam matches of the year.
No.10 seed Kei Nishikori upset the top seed in four sets – 6-4, 1-6, 7-6 (4), 6-3, becoming the first Asian man to reach a Grand Slam singles final.
Novak reached his eighth consecutive US Open semi-finals with a 7-6 (1), 6-7 (1), 6-2, 6-4 win over Andy Murray on Wednesday night.
2011 titlist powered into the last eight at Flushing Meadows on Monday, with a 6-1, 7-5, 6-4 victory over no.22 seed Philipp Kohlschreiber.