Wildcard Denis Istomin prevailed in five grinding sets after four hours and 48 minutes of play at Rod Laver Arena on Thursday.
The defending champion passed a tough first-round assignment with a 6-1, 7-6, 6-2 victory over Spaniard Fernando Verdasco (ATP #40).
Second seed and six-time defending champion will open campaign in his 13th Australian Open appearance against world no.40 Fernando Verdasco.
The six-time Australian Open champion hosted “A Night with Novak” at Margaret Court Arena, to raise funds for the Novak Djokovic Foundation.
Nole claimed his 11th Grand Slam trophy with a 6-1, 7-5, 7-6 (3) victory over 2nd seed Andy Murray in two hours and 53 minutes.
Defending champion beat no.3 seed Roger Federer 6-1, 6-2, 3-6, 6-3 to progress to his sixth final in nine years at Melbourne Park.
The top seed beat Gilles Simon 6-3, 6-7 (1), 6-4, 4-6, 6-3 on Rod Laver Arena in a hard-fought four hours, 32-minute fourth round clash on Sunday.
Novak recorded a 6-1, 7-5, 7-6 (6) victory over Andreas Seppi in two hours and 21 minutes on Friday to move into the last 16 at the Australian Open.
Nole cruises into the second round after a comfortable win over Hyeon Chung 6-3, 6-2, 6-4.
Nole beat Gilles Muller 6-4, 7-5, 7-5 to reach the Australian Open quarter-finals for the eighth time.