The Serbian star dismissed Hubert Hurkacz of Poland 6-4, 6-2, 6-2 in one hour and 36 minutes to reach the second round in Paris. Novak will next face Swiss lucky loser Henri Laaksonen (ATP #104)
Novak beat Andy Murray 3-6, 6-1, 6-2, 6-4 to complete the career Grand Slam, and became just the eighth man to accomplish the feat.
The second Grand Slam of the season, the Roland Garros, is taking place in Paris, from May 22 to June 5, 2016.
After winning the Australian Open and the first two Masters 1000 events in 2015, Novak is full of confidence ahead of the European clay-court swing.
Novak participated in the Kids' Day program on Saturday, playing an entertaining doubles match with several other players from Serbia, Croatia and Bosnia.