Novak defeated the big hitting Argentine 6-4, 7-6 (3), 6-1 to progress in two hours and 15 minutes under the Arthur Ashe Stadium roof. Next up for the top seed is Denis Kudla (USA, ATP #111).
Defending champion advanced into the last 16 at the Western & Southern Open on Tuesday, following a 7-5, 6-1 win over world no.45 Sam Querrey. The match lasted one hour and 18 minutes.
Novak booked his spot in the third round with a 6-3, 7-5, 6-4 win over 2008 finalist Jo-Wilfried Tsonga. He goes on to play 19-year-old NextGen Canadian Denis Shapovalov on Saturday
Novak continued his bid for a third title at the Qatar ExxonMobil Open. The top seed rallied from a set down to beat world no.36 Marton Fucsovics 4-6, 6-4, 6-1 and advance into the ATP 250 tournament quarters
Second seed Novak Djokovic began his quest for a record fourth Rolex Shanghai Masters championship when he defeated Jeremy Chardy 6-3, 7-5 on Tuesday.
Two-time former champion overcame second-round hurdle in New York, moving past American Tennys Sandgren 6-1, 6-3, 6-7 (2), 6-2. Novak faces 26th seed Richard Gasquet (FRA) for a place in the last 16