Novak advanced past the Argentine 4-6, 6-4, 6-4 in two hours and 38 minutes to move to 12-4 in their ATP Head2Head series.
The reigning Paris Masters champion beat world no.34 Gilles Muller 6-3, 6-4 and next faces no.14 seed Grigor Dimitrov (Thursday).
Nole began his title quest at the ATP Masters 1000 event with a comfortable 6-3, 6-3 victory over world no. 50 Fabio Fognini.
The top seed and defending champion will face Mikhail Youzhny (RUS) in the third round on Friday.