No.1 seed defeated world no.66 Aljaz Bedene 6-2, 6-3, 6-3 to reach the last 16 of Roland Garros.
Nole claimed his 11th Grand Slam trophy with a 6-1, 7-5, 7-6 (3) victory over 2nd seed Andy Murray in two hours and 53 minutes.
Defending champion beat no.3 seed Roger Federer 6-1, 6-2, 3-6, 6-3 to progress to his sixth final in nine years at Melbourne Park.
Nole produced dominant display against no.7 seed Kei Nishikori, sealing a commanding 6-3, 6-2, 6-4 victory to set up a last four encounter with Roger Federer.
The top seed beat Gilles Simon 6-3, 6-7 (1), 6-4, 4-6, 6-3 on Rod Laver Arena in a hard-fought four hours, 32-minute fourth round clash on Sunday.
Novak is no.2 seed. He will start his bid for a seventh Grand Slam title against world no.90 Lukas Lacko of Slovakia.
Third-seeded Novak Djokovic came back from two sets to one down to beat his friend and compatriot world no.47 Viktor Troicki 6-3, 3-6, 2-6, 7-5, 6-3 in 3 hours and 40 minutes on Arthur Ashe Stadium on Tuesday.
During the show, the audience had an exclusive opportunity to see how Novak celebrated winning his second Grand Slam title with his team and friends.