The top seed booked his place in the Dubai Duty Free Tennis Championships last eight, following a convincing 6-3, 6-1 win over German Philipp Kohlschreiber. For a spot in the ATP 500 event semi-finals, Novak will face no.7 seed Karen Khachanov.
Top-seeded Novak rallied from 3-5 down in the first set to beat French lucky loser Corentin Moutet 7-6, 6-4 on Wednesday, kicking off his quest for a fifth Rolex Paris Masters title.
Novak defeated the big hitting Argentine 6-4, 7-6 (3), 6-1 to progress in two hours and 15 minutes under the Arthur Ashe Stadium roof. Next up for the top seed is Denis Kudla (USA, ATP #111).
Defending champion advanced into the last 16 at the Western & Southern Open on Tuesday, following a 7-5, 6-1 win over world no.45 Sam Querrey. The match lasted one hour and 18 minutes.
Novak booked his spot in the third round with a 6-3, 7-5, 6-4 win over 2008 finalist Jo-Wilfried Tsonga. He goes on to play 19-year-old NextGen Canadian Denis Shapovalov on Saturday