The 2016 US Open draw will be led by reigning champion Novak, followed by Olympic gold medalist Murray, Wawrinka and Nadal.
Novak has withdrawn from the Western & Southern Open due to recurring injury. His next event will be the US Open.
Nole suffered a tough 6-7 (4), 6-7 (2) defeat to Juan Martin del Potro at the Rio Olympics on Sunday evening.
The Serbian duo won their opening round match 6-2, 6-2 against Croatian combination of Marin Cilic and Marin Draganja.
Novak is a top seed and will open his campaign in singles competition against world no.145, Juan Martin del Potro (ARG).
Nole won his fourth Rogers Cup championship and 66th career trophy with a 6-3, 7-5 victory over no.3 seed Kei Nishikori in Toronto final.
Novak beat no.10 seed Gael Monfils 6-3, 6-2 on Saturday in the semi-finals and improved to a 50-4 match record on the season.
Novak’s bid for a fourth title at the Rogers Cup continued with a 7-6, 6-4 victory over no.5 seed Tomas Berdych on Friday.
Three-time former champion beat world no.129 Radek Stepanek 6-2, 6-4 to advance into the last eight in Toronto.
Nole defeated Gilles Muller 7-5, 7-6 (3) for a place in the third round of the Canada Masters on Wednesday.
29.08. - 11.09.2016.
New York, USA