Novak beat the Next Generation star Borna Coric (ATP #40) 6-2, 6-4 in 78 minutes to move into the last 16 at Caja Mágica.
World no.1 arrived in Madrid with a 28-2 record on the season. The 2011 champion will open campaign against Borna Coric (CRO).
Novak has been named the Sportsman of the Year for 2015, at the Laureus World Sports Awards at the magnificent Messe Berlin on Monday.
World no.55 Jiri Vesely ended Novak’s Monte-Carlo Rolex Masters campaign with a 6-4, 2-6, 6-4 win in two hours and six minutes on Wednesday.
Novak is a top seed and has a first-round BYE. He will open his campaign against world no.55 Jiri Vesely (CZE).
After winning Doha, the Australian Open and the first two Masters events in 2016, Novak is full of confidence ahead of the European clay-court swing.
World no.1 continued his impressive run of form, winning the Miami Open over Kei Nishikori 6-3, 6-3 at Key Biscayne on Sunday.
Novak reached his 40th career ATP Masters 1000 final and will attempt to win record 28th Masters crown on Sunday.
Nole produced a commanding display on Wednesday night to beat Tomas Berdych 6-3, 6-3 and set up clash with David Goffin.
Novak defeated no.14 seed Dominic Thiem to reach the Miami Open presented by Itaú last eight. He next faces Tomas Berdych (CZE, 7).
08.05. - 15.05.2016.