The 2013 Monte Carlo titlist finished semi-finalist to Roger Federer last year, 5-7, 2-6.
Novak, who lifted the trophy at the Caja Magica in 2011, was forced to withdraw from the event last year due to a right arm injury.
Last year, Novak won his third Rome Masters crown with a 4-6, 6-3, 6-3 victory over Rafael Nadal in the final.
French Open is a major tennis tournament held over two weeks between late May and early June in Paris, France. Last year, Novak fell to the nine-time winner Rafael Nadal 6-3, 5-7, 2-6, 4-6 in the final.