After capturing the Rome Masters title, Novak returns to Roland Garros with a chance to win his 18th Grand Slam title.
Singles draw has been made for the third Grand Slam event of the season, taking place in Paris, from September 27 to October 11.
The 2020 edition of the only clay court major tournament was moved to September due to the COVID-19 pandemic.
The French Open first round matches will be played during the first three days of the competition.
Top seed and 2016 champion Novak will open his campaign against world no.80 Mikael Ymer (SWE). It will be their first career encounter.
Djokovic might face Ricardas Berankis (LTU) or Hugo Dellien (BOL) in round two.
Novak’s potential opponents in the later stages of the tournament are:
3rd round: Hubert Hurkacz (POL, 29), Tennys Sandgren (USA)
4th round: Karen Khachanov (RUS, 15), Cristian Garin (CHI, 20)
Quarter-finals: Matteo Berrettini (ITA, 7), Roberto Bautista Agut (ESP, 10)
Semi-finals: Daniil Medvedev (RUS, 4), Stefanos Tsitsipas (GRE, 5), Denis Shapovalov (CAN, 9)
Finals: Rafael Nadal (ESP, 2), Dominic Thiem (AUT, 3), Alexander Zverev (GER, 6), Gael Monfils (FRA, 8), Diego Schwartzman (ARG, 12), Fabio Fognini (ITA, 14), Stan Wawrinka (SUI, 16)…
It will be Novak’s 16th appearance on Parisian clay (68-14 record).
His 2019 French Open run came to an end when he suffered a semi-final defeat by Dominic Thiem (2-6, 6-3, 5-7, 7-5, 5-7).