Singles draw has been made for the second Grand Slam of the season, the Roland Garros, taking place in Paris, from May 27 to June 10. The French Open first round matches will be played during the first three days of the competition
The Austrian sixth seed beat the defending champion in straight sets 7-6 (5), 6-3, 6-0 in two hours and 15 minutes.
Novak continued his good run on Parisian clay as he defeated Albert Ramos-Vinolas 7-6 (5), 6-1, 6-3 to reach the last 8.
The second seed moved into the French Open R4 for the 11th time with a five-set win over Diego Schwartzman.
Novak won his first French Open title in 2016 and completed career Grand Slam beating Andy Murray in the final (3-6, 6-1, 6-2, 6-4).
With a 6-3, 6-1, 6-4 victory over 13th seed Dominic Thiem, Nole is one match win away from completing a career Grand Slam.
Novak cruised into his 30th Major semi-final with a 6-3, 7-5, 6-3 victory over no.7 seed Tomas Berdych on Thursday.
The Serbian ace is in the final eight at a Grand Slam for the 28th consecutive time, surpassing Jimmy Connors for second best streak ever.
No.1 seed defeated world no.66 Aljaz Bedene 6-2, 6-3, 6-3 to reach the last 16 of Roland Garros.