The world no.1 beat no.6 seed 7-6 (5), 6-7 (4), 6-3, 6-0 to win an eighth major, joining Jimmy Connors, Ivan Lendl and Andre Agassi in fifth place on the Open Era major titles list.
Novak advanced to his fifth final at Melbourne Park as he fought past no.4 seed and defending champion Stan Wawrinka 7-6 (1), 3-6, 6-3, 4-6, 6-0 on Friday. He faces Murray for title.
Novak ousted world no.88 Andrey Kuznetsov in straight sets 6-0, 6-1, 6-4 in one hour and 24 minutes on Thursday to ease into the third round in Melbourne.