The defending champion overcame a slow opening to beat German Jan-Lennard Struff 7-6 (1), 6-3 in one hour and 27 minutes.
Novak is no.2 seed and will open his title defence campaign against Jan-Lennard Struff (ATP #63). It will be their first career meeting.
Nole beat Rafael Nadal for the 60th ATP title of his career, and became the 10th player in the Open Era to reach the 60-titles milestone.
Nole reached his 16th consecutive final and improved his ATP H2H record against the Czech to 22-2.
The top seed dropped serve twice but finished match in straight sets (6-3, 7-5) to move into the Qatar ExxonMobil Open last four.
Novak continued bid for his first title in 2015 with a 6-2, 6-1 victory over Sergiy Stakhovsky of Ukraine at the Qatar ExxonMobil Open on Wednesday.