Nole defeated 10th seed Denis Shapovalov 7-6 (3), 7-5, 7-5 to set a championship showdown against seventh seed Matteo Berrettini.
Novak continued his quest for a third consecutive Wimbledon title with a 6-3, 6-4, 6-4 win over unseeded Marton Fucsovics on Centre Court. He will face Denis Shapovalov (CAN, 10) in Friday's semi-final.
The top seed defeated American qualifier, world no.114 Denis Kudla, 6-4, 6-3, 7-6 (7) to reach the fourth round of Wimbledon. He goes on to face no.17 seed Cristian Garin of Chile on Monday (1-0 H2H).
Novak defeated the big hitting Argentine 6-4, 7-6 (3), 6-1 to progress in two hours and 15 minutes under the Arthur Ashe Stadium roof. Next up for the top seed is Denis Kudla (USA, ATP #111).
Novak started his title defence in a strong fashion by beating Roberto Caraballes Baena in straight sets, 6-4, 6-1, 6-4. He next faces Juan Ignacio Londero (ARG, ATP #56).
Defending champion advanced into the last 16 at the Western & Southern Open on Tuesday, following a 7-5, 6-1 win over world no.45 Sam Querrey. The match lasted one hour and 18 minutes.
The defending champion cruised through his fourth round match with a 6-3, 6-2, 6-3 victory over Ugo Humbert in one hour and 42 minutes, reaching the last eight of a major for the 45th time. He goes on to face no.21 seed David Goffin (5-1 H2H) on Wednesday.