The defending champion began his quest for a fifth Wimbledon title with a 6-3, 7-5, 6-3 victory over Philipp Kohlschreiber. He goes on to face ATP no.111 Denis Kudla, in round two on Wednesday.
The third Grand Slam of the season will be held from July 1-14, at the All England Lawn Tennis Club. In his 15th appearance at Wimbledon, Novak will open title defence campaign against world no.57 Philipp Kohlschreiber (GER) in their 13th career meeting (10-2 H2H).
Top seed and defending champion suffered his sixth match loss of a season on Tuesday in his second RR match at the Barclays ATP World Tour Finals.
Nole came up against his toughest test this week, but prevailed to clinch a 7-6 (3), 7-6 (8) victory in two hours and seven minutes.
The top seed from Serbia enjoyed a crushing 6-2, 6-2 victory over John Isner (USA, 6) to book his place in the China Open last on Friday.