After helping Serbia to reach the Davis Cup semi-final, Novak begins preparations for the European clay-court swing.
The reigning Paris Masters champion beat world no.34 Gilles Muller 6-3, 6-4 and next faces no.14 seed Grigor Dimitrov (Thursday).
With a 6-3, 6-1, 6-4 victory over 13th seed Dominic Thiem, Nole is one match win away from completing a career Grand Slam.
Novak cruised into his 30th Major semi-final with a 6-3, 7-5, 6-3 victory over no.7 seed Tomas Berdych on Thursday.
The Serbian ace is in the final eight at a Grand Slam for the 28th consecutive time, surpassing Jimmy Connors for second best streak ever.
No.1 seed defeated world no.66 Aljaz Bedene 6-2, 6-3, 6-3 to reach the last 16 of Roland Garros.