The victory over Gael Monfils in the Aegon International final gives Nole his fourth grass-court crown and first outside Wimbledon.
Nole successfully defended his Qatar ExxonMobil Open crown with a 6-3, 5-7, 6-4 victory over top seed Andy Murray in Doha.
Novak completed the 2016 season with a 65-9 W/L record and seven titles won, and finished year as no. 2 for the second time in his career.
Nole failed in attempt to win his third title in New York, and his 13th career GS crown, when he lost to no.3 seed Stan Wawrinka 7-6 (1), 4-6, 5-7, 3-6.
The world no.1 and four-time champion lost the Italian Open final to no.2 seed Andy Murray 3-6, 3-6 in one hour and 35 minutes.
World no.1 continued his impressive run of form, winning the Miami Open over Kei Nishikori 6-3, 6-3 at Key Biscayne on Sunday.
Nole claimed his 11th Grand Slam trophy with a 6-1, 7-5, 7-6 (3) victory over 2nd seed Andy Murray in two hours and 53 minutes.
Nole beat Rafael Nadal for the 60th ATP title of his career, and became the 10th player in the Open Era to reach the 60-titles milestone.
Novak was attempting to win his 50th career title and second in 2015. Roger Federer won 6-3, 7-5 to take his seventh Dubai crown.
World no.1 beat Roger Federer 7-6 (6), 7-5 in the final of the season-ending event in London to capture his 34th career title.